The Sustainable Development Goals (SDGs) of the UN 2030 Agenda are today’s global roadmap to sustainable development. Adopted in 2015, the SDGs are the culmination of 50 years of debate and consensus building on the imperatives of sustainable development. The 2030 Agenda explicitly calls for integrated methods for SDG achievement. Two multisector modeling frameworks have emerged to address integration in SDG policy: the system dynamics based Integrated Sustainable Development Goal (iSDG) model and the multimethod International Futures (IFs) model. Both are feedback rich and thoroughly integrated, and we term them as Integrated Systems Models (ISMs). ISMs enable quantification of policy impacts across SDG sectors, helping identify policies that benefit numerous SDGs as well as potential trade-offs. These benefits have been witnessed in countries where these ISMs have been put to task on SDG policy. As the sustainable development paradigm becomes increasingly integrated, a central role is being created for further development of ISMs.