A new system dynamics tool, T21-Ohio, was developed to support integrated and comprehensive development planning at the state level. Based on the Threshold 21 (T21) framework, T21-Ohio provides insights into the potential impacts of energy and environmental policies across a wide range of sectors, and reveals how different strategies interact with one another to achieve planned goals and objectives. This paper shows how T21-Ohio was used to model the broader social, economic and environmental impacts of “waste to profit” activities in Ohio, such as recycling, electricity generation from waste, and bio-fuel production. Three alternative scenarios were simulated to evaluate the impacts of biomass co-firing, government stimulus for solid waste recycling, and by-product synergy activities. The results of the three scenario analyses indicate significant potential for economic development and creation of jobs while reducing emissions and waste.